This was the first reported case of an acquired agammaglobulinemia in a thirty-year old female who had repeated severe infections such as pneumonia, meningitis and other bacterial infections.  Prior to this report, it was believed that agammaglobulinemia occurred as a genetic sex-linked disorder affecting only male children.  Several examples of cases of acquired agammaglobulinemia were reported subsequently confirming our report that agammaglobulinemia was not only a sex-linked disorder affecting male children but also an acquired variety of this disorder affected young adults of both sexes.

Ref.  Prasad, A.S., Koza, D.W. Agammaglobulinemia.  Ann. Intern.   Med., 41:629‑639, 1954.