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Dr. Ananda Prasad: Comment #8

Comment #8

#8.  Comment:  In this paper, we reported a detailed clinical and genetic studies in an American Black family which segregated for sex-linked sideroblastic and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency.  This was the first such pedigree reported in the literature.  This family provided us with unique opportunity to study the linkage of the two genes and to study the relationship of the cellular expression of the genes in various genotypes, particularly double heterozygotes.  Prior to this report, these subjects were misdiagnosed to have Thalassemia.

Ref.

Prasad, A.S., Tranchida, L., Konno, E.T., Berman, L., Albert, S., Sing, C.F., Brewer, G.J.  Hereditary sideroblastic anemia and glucose‑6‑ phosphate dehydro-genase deficiency in a negro family.  J. Clin. Invest., 47:1415‑1424, 1968.